Are you sure you're taking it with enough clear water? It needs to be chased down with a full glass.
As said above, take it on an empty stomach. If you take it with food, the food will absorb it before your system has a chance to, hence nullifying it.
Good luck.
I suffer from acid reflux also, but you need to take the synthroid as directed for maximum absorption.
NO take it on empty stomach. If your acid persists, maybe try something else, unfortunately I to have this problem. But I can deal. It will take some time for your body to adjust. So just make sure you talk to your doctor.
Take in morning WITH EMPTY STOMACH....
Very important.....read the inserts...or go on line ...