Aa
Thyroid
My husband had a biospy done diagnosis benion follicular adenolipoma see comment> Immunostains were performed to rule out intrathyroidal parathyroid tissue and medullary carcinomal. the stains show the neoplastic cells to be positive for ttf-1 and thyroglobulin, with rare cells positive for cyclin D1 Taken togethr these findings support the diagnosis of adenolipoma a rare variant of follicular adenoma. What is this mean? Should we have a second opinion. Anybody could help me mabe just to explain thanks
Somethings just don't make sense.Because the stains show the neoplastic cells to be positive for ttf-1 and thyroglobulin with rare cells positive for cyclin d1.My husband goes to the doctor today I'll get back with you and let you know what he says Thanks for your infomation.
mae59
mae59
Wow - try posting this to the expert forum but I'll try to help.
This is what I found on a doctor's website that addresses follicular adenoma (if you want the site I'll try to send it to you in a message 'cause I know MedHelp will scrap it - but I'll try posting it below):
(note - I replaced some of the common punctuation with ( ) in hopes it makes it through)
(www)thedoctorsdoctor(dot)com/diseases/thyroid_follicular_adenoma(htm)
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The follicular adenoma of the thyroid is a common benign tumor of the thyroid gland. They present as a solitary nodule, usually as a painless mass. It may be found during a routine physical examination. A physician may order a nuclear medicine thyroid scan which measures uptake of radionucleotide labelled iodine. Adenomas are usually cold nodules since they usually take up less radioactive iodine than normal surrounding gland. On the other hand, about 10% of cold nodules are malignant. Conversely, hot nodules are only rarely malignant.
Once the nodule is identified, additional diagnostic techniques including an ultrasound examination which may identify a cystic component may be helpful. A pathologist may perform a fine needle aspiration biopsy to obtain diagnostic cytology. In the case of a follicular adenoma, a diagnosis of follicular neoplasm-adenoma versus carcinoma, may be rendered. On cytologic examination, a pathologist cannot make the distinction between an adenoma versus a carcinoma. An excisional biopsy must be obtained. The pathologist must carefully embed the entire capsule in order to exclude capsular invasion, the hallmark of malignancy.
Among the follicular neoplasms of the thyroid, the definition and nature of atypical adenoma have been confusing. Despite the original speculation about the biologic behavior of preinvasive malignancies, this term is currently used as an expression of uncertainty.
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I would suggest a second opinion and, perhaps, follow what the article suggests (an excisional biopsy)
The definition of adenolipoma I found means a mass (or tumor) consisting of glandular and fatty tissues.
Please let us know what your husband's symptoms have been, family history of thyroid problems, etc. Maybe we can help a bit more.
Best of everything to you and your husband
Utahmomma
papillary carcinoma and 3 sisters with papillary carcinoma
This is what I found on a doctor's website that addresses follicular adenoma (if you want the site I'll try to send it to you in a message 'cause I know MedHelp will scrap it - but I'll try posting it below):
(note - I replaced some of the common punctuation with ( ) in hopes it makes it through)
(www)thedoctorsdoctor(dot)com/diseases/thyroid_follicular_adenoma(htm)
******************************************
The follicular adenoma of the thyroid is a common benign tumor of the thyroid gland. They present as a solitary nodule, usually as a painless mass. It may be found during a routine physical examination. A physician may order a nuclear medicine thyroid scan which measures uptake of radionucleotide labelled iodine. Adenomas are usually cold nodules since they usually take up less radioactive iodine than normal surrounding gland. On the other hand, about 10% of cold nodules are malignant. Conversely, hot nodules are only rarely malignant.
Once the nodule is identified, additional diagnostic techniques including an ultrasound examination which may identify a cystic component may be helpful. A pathologist may perform a fine needle aspiration biopsy to obtain diagnostic cytology. In the case of a follicular adenoma, a diagnosis of follicular neoplasm-adenoma versus carcinoma, may be rendered. On cytologic examination, a pathologist cannot make the distinction between an adenoma versus a carcinoma. An excisional biopsy must be obtained. The pathologist must carefully embed the entire capsule in order to exclude capsular invasion, the hallmark of malignancy.
Among the follicular neoplasms of the thyroid, the definition and nature of atypical adenoma have been confusing. Despite the original speculation about the biologic behavior of preinvasive malignancies, this term is currently used as an expression of uncertainty.
*************************************
I would suggest a second opinion and, perhaps, follow what the article suggests (an excisional biopsy)
The definition of adenolipoma I found means a mass (or tumor) consisting of glandular and fatty tissues.
Please let us know what your husband's symptoms have been, family history of thyroid problems, etc. Maybe we can help a bit more.
Best of everything to you and your husband
Utahmomma
papillary carcinoma and 3 sisters with papillary carcinoma
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