So I am on a lot of different pain killers (vicoden, percocet and oxycotten), never combined, but my pain fluctuates and I take what I need. I am on the pain meds for an injury to my hand that got infected and I ended up having a Proximal Row Carpectomy (removal of a row of bones out of the wrist). This has been a LONG process and that was not my only surgery just the most current. Lately I have been VERY depressed and it comes in waves, making it hard to do even simple tasks, wanting to cry uncontrollably for no reason. To be clear I am also on Lexapro, Abilify, Pravastatin, Trazodone, and Amlodopine. Nothing has really changed recently. So my question in all of that is this: can the pain killers cause the depression, and if so is there anything (short of getting off them) that I can do to lessen it or get rid of it?