My unresearched, non-scientific answer is no. I think it is more of a behavioral inheritance. We see our family/friends using substances to cope with life, and that's what we learn. Drugs have been around since mans beginnings, unfortunately we hippies didn't start it lol. We just took it out of the closet.
I believe it runs in families, my mom was an addict...my grandpa drank, a few cousins etc