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Can Remicade Cause Depression and Mood Swings

My husband takes Remicade for Crohn's Disease. He has severe mood swings after taking Remicade and then high and lows that resemble Depression. Are there any reported cases of this happening with anyone else?
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Avatar universal
My boyfriend of ten years just had his second infusion of remicade.  A couple days later he threw some tantrums and jumped out of a moving car.  He's increasingly insecure and suspicious of EVERYTHING. HE HAS PSORIATIC ARTHRITIS. The same happened after his first infusion.  He said he had thoughts of suicide.
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Avatar universal
Hi couldbeworse,

        I've noticed the same with my husband...my husbans is the most relaxed, funniest guy. After this 4th remicade..it's so bad..he won't even admit there's a problem..he gets angry..emotional. I have never seen him this way. I'm scared it won't go away. There is not enough research...and they won't tell us straight up...it's too profitable....It seems each doctor has their own philosophy. I just want him back..this is not him. Any insights?
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Avatar universal
Hello...my husband and I married 3 and a half years ago and sated for 2. He was diagnosed with UC a few years before I met him. Hos colitis demands us to make health changes which is great for us. We are super advebturous...love being outdoors and are incredibly active people-people. This time after his 4th REMICADE injection....after about 2 weeks more or less..he woke up and was a different person. I didn't get it...I was so hurt...a few days later I figured it out and made the connection. I had even repeatedly asked him what it was..sometimes aggressively before I realized it was the remicade. I remember his parents saying during his first initial flare...he got like this with remicade ans homeopathic medicine for mood helped initially until the reaction faded. I have not seen him this way ever..he is the most hilarious, funny, sensitive man...he loves photography, travelling etc. Remicade has created someone I don't know...withdrawn, dis interested in hobbies, angry. It is so difficult..I don't know what to do. Is this permanent..will it last forever? He is so loving and now can't stand anyone. I called his doctor but his doctor is one of those who would NEVER blame medicine...he believes he is the holder of all knowledge right and this must just be my husband. I think I know mt husband! I think his parents know him..through difficult times..he holds his head up high..but now. Luckily they are stopping the Remicade because he's built antibodies to it. Please help...will this go away...I have stuck by him through difficult flares..I love him. This is so difficult...I want my husband back.
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1530171 tn?1448129593
Hi Renatho.
Look into the SCD program.
If it makes sense to you and you have the discipline to follow it,
it could help you get your life back.

Your mood swings along with weakness and "brain fog" are likely due to the imbalances caused by malabsorption and deficiencies, hallmark characteristics of UC.

Hope this helps.
Best wishes,
Niko
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Avatar universal
Hello guys, my name is Renatho Azevedo, I'm from Brazil. I was diagnosed with Ulcerative Colitis in 2010, I took mesalazine and azatioprine, which worked at first but for not too long. The only thing that work for me and make me feel like have no colitis is corticosteroids, but the side effect for a long period doesn't worth. I have been taking remicade for almost a year and half now, I also have severe mood swings with highs and lows, sometimes i feel like i can't think straight. I feel weak, without motivation, no social life and all other stuffs that all of you commented here. This is so frustrating...
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1530171 tn?1448129593
Immunosuppression, as much as the biologics' makers claim to be targeted,
still leaves the patient vulnerable to its effects, some of which include survival of unregulated low grade underlying infectious conditions , causing all types of damage when activated by various factors
The cumulative biological stress (hidden) added to the stress experienced daily by the sufferers of such serious chronic conditions, is enough to cause significant adrenal/hormonal and other deficiencies and imbalances.

Meditation: It is not as simple to get into it when suffering with severe plaque psoriasis or other severe chronic conditions.
I suggest you do a search under "Brain Wave Generator" .
The free software program will help you get into a therapeutic meditative state.

Cheers!
Niko
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