Here is a regimen you can follow. Fibroscan every year would be good. Be careful getting it when you have an ALT flare, you could get false positives.
Preliminary Information:
1. How long you have had HBV? (example, birth, don’t know)
2. Family history of Liver Cancer HCC
3. HBV Genotype
Group1: every 6 months (Virus and Immune activity monitoring)
1. Liver Enzymes (ALT, AST) + .
2. HBV DNA
3. HBsAg Quantitative
4. HBeAG – only if previously positive
5. Liver Function Tests (Bilirubin, Albumin, platelette counts)
Group 2: every 6 months (HCC Screening)
1. AFP
2. DCP des-gamma carboxy prothrombin
3. AFP-L3%
4. Ultrasound (Liver contour, Spleen Size, Portal Vein Diameter) especially over age of 40
Group 3: every year
1. Fibroscan
2. Fibrosure / Fibrospect
Group 4: (every few years if HBVDNA detectable)
1. Precore/Core Mutation