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A combinatorial approach from Alnylam: Ent/RNAi/shHBV/Vaccine
This poster from EASL2017 was embargoed. U. Protzer was one of the authors.
http://www.alnylam.com/web/assets/EASL-2017_HBV-Poster-240317.pdf
Pre-Clinical Data with a Combinatorial RNAi / Vaccination Therapy as a potential Functional Cure for Chronic Hepatitis B Virus InfectionLBP-538
Preclinical study of a combinatorial RNAi / vaccination therapy as aPotential cure for chronic hepatitis BT. Michler1,2, A. Kosinska1, T. Bunse1, M. Heikenwälder1,3, D. Grimm3,S. Milstein 4, L. Sepp-Lorenzino 4, U. Protzer 1, 2. 1 Virology, TechnischeUniversität / Helmholtz Zentrum München; 2German Center for InfectionResearch (DZIF), München; 3Virology, University of Heidelberg,Heidelberg, Germany; 4 Alnylam Pharmaceuticals, Cambridge, MA,United StatesE-mail: thomas.***@****
We presented pre-clinical data with a combinatorial RNAi / vaccination therapy for Hepatitis B Virus (HBV) infection at The EASL International Liver Congress, held April 19-23 in Amsterdam, The Netherlands. Treatment with the combination therapy led to an HBV-specific Immune response and sustained loss of HBsAg in a mouse model of chronic HBV infection. We believe this approach holds potential promise for use in a clinical setting to treat patients with hepatitis B.
http://www.alnylam.com/web/assets/EASL-2017_HBV-Poster-240317.pdf
Pre-Clinical Data with a Combinatorial RNAi / Vaccination Therapy as a potential Functional Cure for Chronic Hepatitis B Virus InfectionLBP-538
Preclinical study of a combinatorial RNAi / vaccination therapy as aPotential cure for chronic hepatitis BT. Michler1,2, A. Kosinska1, T. Bunse1, M. Heikenwälder1,3, D. Grimm3,S. Milstein 4, L. Sepp-Lorenzino 4, U. Protzer 1, 2. 1 Virology, TechnischeUniversität / Helmholtz Zentrum München; 2German Center for InfectionResearch (DZIF), München; 3Virology, University of Heidelberg,Heidelberg, Germany; 4 Alnylam Pharmaceuticals, Cambridge, MA,United StatesE-mail: thomas.***@****
We presented pre-clinical data with a combinatorial RNAi / vaccination therapy for Hepatitis B Virus (HBV) infection at The EASL International Liver Congress, held April 19-23 in Amsterdam, The Netherlands. Treatment with the combination therapy led to an HBV-specific Immune response and sustained loss of HBsAg in a mouse model of chronic HBV infection. We believe this approach holds potential promise for use in a clinical setting to treat patients with hepatitis B.
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Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
