Entry inhibitors show promise as drugs

[LilHope2010]

Entry inhibitors like REP9 AC and Myrcludex-B are promising as they are the only drugs that offer a complete CURE for Hepatitis B compared to immune modulators like Pegasys and Anti-virals like Entecavir... I think more research and concentration should be diverted to release inhibitor drugs as they seem to be promising and appropriate....

[miracle852]

Does anybody has contact info for the REP 9AC and Myrcludex-B people...email, phonenumber etc. We can call and contact them and see how to carry the campaign for it. I can't believe, there could be a cure for an infection and some people will just keep it away, allow people to die just because of monetary gain.
Why is minimum investment that high? 25,000 or $50,000 CD is a lot of money?

[miracle852]

How much clinical trials do we have for these drugs also? How successful are they?

[stef2011]

i think 2 clinical trial in india paid by researchers...not even the company because of luck of money
they choosen the worst candidates with hbeag pos and very high hbvdna.hbsag cleared and hbsab antibody as early as 7 days and as late as 15weeks.

a combo of antivirals will make this a bomb because it is possible to have hbsag mutants so it must be comboed interferon or nucs

no sides reported, i think hbeag negative needs to be checked, they only had one in the trials and it didn t respond

[StephenCastlecrag]

Replicor is not listed on the stock exchange, therefore it raises fund its own way. It is not structured to deal with small investors. My understanding is that, the company is funded entirely by its investors many of whom are scientists.

Replicor's website site is: www.replicor.com.

Mycrludex is from the research lab of Prof Stephen Urban:


Stephan Urban
Head of Hepatitis B Research Group

Phone: [phone]
Fax: [phone]

Stephan_Urban***@****-heidelberg.de

[vijik]

guys in india too MNC pharma's has strong presence. Ranbaxy-daichi,piramal-abbott and so on. Last week, in business line daily, they published a detailed report about drug prices in front page itself. The shocking news is that immediately after the every greedy-MNCs acquiring indian companies, they steeply  increased the drug prices. So the Government here considering to control the prices by restricting the doctors to stay away from prescribing the brand name, and instead govt ask them to notify only the chemical  compound in prescription. So you can get prescribed, say for if fever, only paracetamal instead of crocin or some other brand.

The only  pharma companies in india without foreign players' influence are Cipla and sun. Probably they can try.
It's highly unlikely to get approval of some sure-cure drugs like  replicor in US I think. But it's not a big issue to conduct trials here and get approval. But again it's not a simple process.

[LilHope2010]

Nothing is a simple process unless it is handled in the right way....$25,000 may be a huge amount for one HBV carrier but very minute for 3 billion carriers world wide...It is not a bad idea to stimulate a campaign and push the companies to approve the drug in Asian subcontinent....If we succeed in it I can say we are just fast forwarding our struggle to seroconvert in no matter of time...When there is a will there is a way...when we know that something that is going to cure the disease is available we should not waste our time and bang our heads discussing about Immune-modulators or Anti virals....I see so many people desperate to get rid of the disease...I feel it is time to take the steps leading to cure instead of struggling.....After all it is one life,let's strive to make it better by taking better steps and decisions....