[quote]intf and myrcludex will do the rest of the market/job to clear hbv [/quote]
yes lets hope all this comes true for us and soon..
I was put on a antiviral by an entecavir salesman. I thought he was a decent doctor but turned out to be crook.
I had high VL, twice the normal ALT with no liver damage at the time six years ago. And he gave me ETV. Well aware of what he was doing. Then telling me a year later that interferon was my best option. And then he totally dumped me because my insurance did not pay their office enough. and enough for these guys if they get $400-500 for a visit. And this guy does research and is published also. "the so called good doctor" that is.
truvada is just tenofovir+ftc, it is sueless on hbv unless non response to tenofovir, which is extremely rare
it adds toxicity and higher price because truvada patent is not expiring in 2014, no difference on hbsag.
instead of truvada it is best only for those non responding to combo tenofovir+lamivudine.lam is less toxic, is generic, more potent than ftc but of course lam is to be used only in this combo because both lam and ftc used alone are too weak and extreme high resistance
there is no future for these componds, as antivirals tenofovir has already the maximum respose that can be achieved by antivirals and after this will become generic i think antivirals will dye with just the compounds already approved, intf and myrcludex will do the rest of the market/job to clear hbv