hbe seroconversion under nucs is temporary

[stef2011]

as HR said years ago seroconversion to hbe neg and hbeab pos is temporary under nucs and therapy cannot be stopped, only interferon seroconversion is durable and maybe alinia serconversion too since it acts on host and not virus

http://archive.mail-list.com/hbv_research/message/20100417.122929.e06c61b6.en.html

[stef2011]

this is not the article that i read but shows that hbsag gets higher on hbe neg (hope not my case) and gets very little lower on hbe pos
it shows hbsag on hbe pos and hbeneg under interferon or etv therapy

http://www.kenes.com/easl2010/Posters/Abstract908.htm

[stef2011]

as soon as i find it i will post it, i just read that in a rush on the conferences of vienna or apasl in china.
anyway there are many post on this forum as well, i remember a women posted lately that seroconverted to hbeab and got hbvdna und with entecavir but hbsag got higher than when she was untreated

[cajim]

The link please.

[stef2011]

i have found a research with comparison between interferons and nucs and impact on hbsag quantity, on nucs therapy hbvdna undetactable leads even to a higher hbsag on many cases

[stef2011]

well the only point with 100% hbv regression forever is hbsab (without hbsag mutants) which is equal to hbv have left the body forever and the small cccdna that can be left in some patients is neutralized by immune system 100% forever, only suppression of immune system by chemiotherapy can reverse this.
for this there is no trial needed, hbsab is the way hbv is naturally eradicated by immune system in more than 95% of cases when adult

all other smaller results can be or not be forever taking the drugs indefinitely, regress or not but we have no other choice to avoid a bad end

[cajim]

Agree to both.  In addition,

1.  In the early 90s, LAM was looked at much like how REP9 is looked at now.  Isn't it the case that the full understanding of the full impact of a drug takes years if not decades to get?

2.  I have read claims that nucs reverse fibrosis and I have read cases of f3/f4 or less progressing to cirrhosis and ascites despite years of antiviral treatments.  Are there studies that showed initial fibrosis, then nucs, then disappearance of fibrosis?

3.  Read a comment recently that most if not all HBV disease progression could be halted if only the patient can do the right things, always, feeling good or feeling bad, yet when there is no fatigue, liver area discomfort, normal LFT etc, how easy it is to slip into taking a drink of beer, staying up late, enjoying another romantic contact, etc.?  The comment says, we hurt the liver more when everything looks normal.  Agree?

[Sharp7]

Who knows? Maybe the ones that performed especially badly were all on LAM ;-).

I say that because it seems to contradict previously observed results: http://www.ncbi.nlm.nih.gov/pubmed/18662610, and the patient numbers are low, and in this pre-pub report, details are scarce.

[stef2011]

well one thing is certain producers found a good way to make money indefinitely.....

- nucs don't cure anything (at least in 5 years) that's a fact so i think we should check what alinia+etv or +tdf or +truvada does because this is available now with no sides since alinia has shown higher seroconversion than interferon and nucs
i think nucs are ok only for f3/f4 damage to save people from cirrhosis

- interferon plus etv or tdf or truvada are on trial now so most should wait the results since interferon can have heavy sides.

pray for rep9 ac to get on the market soon

[cajim]

What does this study suggest?

All antiviral drugs should be taken indefinitely, or forget about current antiviral drugs?