well you have cronic hbv, it has low replication periods and high replication periods, you are now in the low replication and i'd try nitazoxanide since now virus is weaker and drug has no sides at all (aspirin is by far more toxic as an example), you have nothing to lose and you must make antihbe
as to other therapies i'd wait because they all have sides but liver damage is very important, if you have more than f2 liver damage therapy must be started, look for a center with fibroscan, do not consider biopsy at all too old tool
you have to monitor liver damage closely since normal alt and low hbvdna can make cirrhosis too, i am an exampleof that
Here are my other test results.
Total Bilourabin 16.1 umol/l 3.4 - 21.0 PHOT
Direct Bilourubin 4.6 umol/l 0.8 - 8.5 PHOT
ASAT 17 U/l 4 - 31 PHOT
ALAT 18 U/l 0 - 33 PHOT
GGT 10 U/l < 50 PHOT
ALP 99 U/l 98 - 279 PHOT
I don't have a fibroscan because they offer only bipsy here which I really hope to avoid. My ultrasound is very good. Do you still think that I need treatment? :(((
HBeAg (-)negative
Anti-HBe (-)negative
sorry i didn t noticed antihbe neg, you might try ntz to make antihbe positive and hbvdna und, response is slow but since ntz has no sides time on therapy is not a problem
me and my sister were like that when teens, you are close to seroconversion but there is too much hbsag and cccdna in your liver neutralizing antihbe, the best drug are ntz and interferon but interferon has too many sides
HBeAg (-)negative
Anti-HBe (-)negative
HBcor-Total (+)positive
HBV-DNA 12 000 IU/m
according to guidelines you should start treatment:
what's fibroscan result and alt level?
there are many interesting trials for next year so if fibroscan is <7kpa i'd monitor or start for nitazoxanide which has no sides, if your hbsag is low you have chances to get it negative or get hbvdna und
i would not start nucs now it is better to avoid these drugs now
Hi again! I got my PCR results today and I totally lost any idea of how to interpret them. Please, help with some suggestions:
HBV-DNA 63 000 copies/ml 4,7 log 10
(Real-Time PCR) 12 000 IU/ml 4,0 log 10
Is there a chance to skip treatment? :(
Thanks, Stefano, for the encouraging words. I am waiting for the results of my HVB-DNA test and will keep in touch. Good luck to everybody who is fighting this cunning disease!
also do not worry about hbv, the problem of this disease is that it is a silent killer, most do n t know they have it and reach cirrhosis death or liver cancer death without synthoms except when it is too late and they are dying
once you know hbv can be complitely stopped from making damge even if not eradicated
check that all hbv markers have been requested:
hbcab Igm, hbsag, hbsab, hbvdna pcr with good sensitivity lower than 12iu/ml
make also markers for hcv and hdv, all these viruses like hiv have no synthoms, only a very small percentage have synthoms
biopsy is useless, make fibroscan and if they don t have it change hospital/doctor since it means they are not updated
if he turns out you have the virus check for hbsag by abbott architet hbsag quantification in iu/ml, this might give more info if you are totally inactive or temporarly in inactive phase