My profile and Results

[mike9111]

I'm an HBV carrier since birth like most of the members and I did lot of tests in the past year. My hepatalogist is one of the world leading in HBV professor Anna Lok. My results are fluctuating and I'm on no treatment and never been on treatment. I tried to put as much info on supplements I took and duration as well with the time frame.

2007
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HBV DNA 16120 IU/ML
LIVER BIOPSY  Read negative for Fibrosis

2009
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HBV DNA   160 IU/ML
ALT/AST Within Range

2010
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HBV DNA 13220 IU/ML
ALT/AST Within Range

2011
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HBV DNA   2670 IU/ML
ALT/AST Within Range
Ultrasound  Coarsened Liver

June 2014
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AST  18
ALT   20
HBV DNA 1118 IU/ML
FIBROSCAN    7.6 KPA
Ultrasound  Subtle Coarsened Liver

August 2014 (Test done in Germany)
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AST   25
ALT    39
HBV DNA   38200 IU/ML
HBSAG QUANTITATIVE    223 IU/ML
GENOTYPE   D
Vitamin D   32 ng
Started vitamin D 6000 iu

September 2014
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AST    36
ALT     55
HBV DNA   9472 IU/ML

December 2014
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AST   19
ALT    21
HBV DNA   303 IU/ML (Very low)
Started black Seed every morning with food
Pure Honey one spoon on empty stomach in morning

March  2015
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AST   26
ALT   36
Vitamin D  23 ng
HBV DNA   4608 IU/ML
FIBROSCAN   4.7 KPA (Much lower than previous read from june)

My professor before fibroscan was thinking of trying interfron for a year after i kept asking and she said if fibroscan show worsen than my last reading but it came way below that. She did say few things that align with what Stef and others been saying. I asked her if i should go nuc first to get undetectable DNA before interfron and she said in my case interfron mono would be ok since my hbv dna is not elevated. Also she said that precore mutant will not increase the risk of hcc but the genotype C and basal core are the one that at increase. In all means she said in the next 10 years my risk is low but after that she can't predict. One last thing she also commented on future and she said most hepitits C researchers have to work on HBV or otherwise they will go out of business since HCV is cured.

[stef2011]

i just replied privately but better put it public too so we help others in similar situation

we have see gcmaf and vit d3 can prevent heavy sides from peg, only few members tried this but i think it worths to try this add on to peg.if sides are not heavy suggestion from top researchers is not good because with your low hbsag and genotype d it worths try 12-24 weeks to see response and if no response then go for tdf
if we go to tdf directly we dont know if peg can give an immune boost that may last for 5-10years making a faster hbsag decline on tdf mono

[Aduiski]

I am geno D...so I decided to either start with tdf or entecavir with a most likely switch to taf when it becomes available in australia (2-3 years from now..at that time we'll also have more data on its long-term effectiveness).

I just recently contacted few top-notch research doctors...they are advising me to get on NUCs rather then interferon and wait for upcoming newer medications for hep B.

What is your opinion?

[stef2011]

tdf or peg?

[mike9111]

I expect my next test in 2 month to be decreased because it fluctuate

[Aduiski]

you never know...its an unpredictable disease...
I think getting on treatment would not be a bad idea...since many people enter immune escape phase at around or shortly after 40....

[Bm2016]

I wanted add more info about my previous lab result
the subsequence lab results after May 17th, 2015
, which are in July and December 2015,  hep B DNA quant PCR result, HBV DNA NOT DETECTED.

[Bm2016]

Jan 30 2015 , hbv dna virus  detected 1860iu/ml

May 17th 2015, hbv quant pcr dna not detected

July 25th 2015, alt 52, ast 30
Hep B surf Ag nonreactive
Hep B surf Ab reactive

December 26th, 2015, alt 47, ast 23
Hep b surf Ag nonreactive
Hep b surf Ab reactive