My profile and Results

[mike9111]

I'm an HBV carrier since birth like most of the members and I did lot of tests in the past year. My hepatalogist is one of the world leading in HBV professor Anna Lok. My results are fluctuating and I'm on no treatment and never been on treatment. I tried to put as much info on supplements I took and duration as well with the time frame.

2007
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HBV DNA 16120 IU/ML
LIVER BIOPSY  Read negative for Fibrosis

2009
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HBV DNA   160 IU/ML
ALT/AST Within Range

2010
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HBV DNA 13220 IU/ML
ALT/AST Within Range

2011
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HBV DNA   2670 IU/ML
ALT/AST Within Range
Ultrasound  Coarsened Liver

June 2014
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AST  18
ALT   20
HBV DNA 1118 IU/ML
FIBROSCAN    7.6 KPA
Ultrasound  Subtle Coarsened Liver

August 2014 (Test done in Germany)
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AST   25
ALT    39
HBV DNA   38200 IU/ML
HBSAG QUANTITATIVE    223 IU/ML
GENOTYPE   D
Vitamin D   32 ng
Started vitamin D 6000 iu

September 2014
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AST    36
ALT     55
HBV DNA   9472 IU/ML

December 2014
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AST   19
ALT    21
HBV DNA   303 IU/ML (Very low)
Started black Seed every morning with food
Pure Honey one spoon on empty stomach in morning

March  2015
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AST   26
ALT   36
Vitamin D  23 ng
HBV DNA   4608 IU/ML
FIBROSCAN   4.7 KPA (Much lower than previous read from june)

My professor before fibroscan was thinking of trying interfron for a year after i kept asking and she said if fibroscan show worsen than my last reading but it came way below that. She did say few things that align with what Stef and others been saying. I asked her if i should go nuc first to get undetectable DNA before interfron and she said in my case interfron mono would be ok since my hbv dna is not elevated. Also she said that precore mutant will not increase the risk of hcc but the genotype C and basal core are the one that at increase. In all means she said in the next 10 years my risk is low but after that she can't predict. One last thing she also commented on future and she said most hepitits C researchers have to work on HBV or otherwise they will go out of business since HCV is cured.

[StephenCastlecrag]

Thank you for your post. HBV has many mysteries, virological breakthrough(increase in hbvdna) during antiviral treatment is one of them. Why?What is the mechanism? Sometimes virological breakthroughs can be attributed to non-compliance, but some seem to have no explanation.
Can I clarify, you have developed HBsAb but you are still HBsAg positive?

[Bm2016]

my hbv dna went undetected for a few years, (maybe since 2009 or 2010),  and I've been taking viread daily. Last January, blood work shown sudden spike in hbv dna, and dr also asked me to do another blood work in 2 months as well, I was trying to blame the delicious New York steak once from Costco I ate a week before the bloodwork, then in May 2015, HBV dna went undetected again, and July 2015 bloodwork, HBV surf anti-body developed.  It is possible the immune system need some stimulation rom hbv dna to make hbv surf anti-body.

[mike9111]

After losing control i assume they started you on treatment? Or were you on treatment from the begining?

[Aduiski]

I'll start the treatment in few days...

[mike9111]

I just don't get the difference in fluctuating 2 to 3 logs

[Aduiski]

I was fluctuating like that too...untill started loosing control of my virus...

[mike9111]

Ya that is why i went to my general physiscians in june for ultrasound :)

[mike9111]

I just completed another set of testing and doesn't look good. Seems viral load is at highest as seen.
March 07 2016
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AST   23
ALT    40
Vitamin D    21 ng
Hbv DNA     26773 iu/ml
The Professor asked me to repeat in 2 months and if still elevated then she will put me on treatment.

[Aduiski]

well...you'll see what will happen in 2 months mike...

[sorte]

You professor is statistically right, but ultrasound is not so expesive so I think you should make tests anyway every 6 months, better react early than regret.
Notice that all recomendations is the consensus between medical knowledge and money to spent by healthcare :)