Rapid increase in ALT and AST (I am in panic, please help)

SafiSifa

Dear Friends,

I am on Entecavir treatment for 5 months.

5 months ago
ALT: 86
HBV DNA: 557 000 000

2 months ago
ALT: 90
HBV DNA: 55 000

This Week
ALT 347
HBV DNA: not resulted yet.

As you see my ALT increased rapidly in the last 2 months. My doctor says It may be because of (1) mutation or (2) sport+eating protein. They want me to wait HBV DNA result.

Dear Stef and other friends. Please share your comments. I am in panic.

Regards.

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Best Answer

stef2011

resistance to etv so fast is extremely unlikly, hbvdna is also too low to be the virus to induce the flare

it is hbeag seroconversion and lowering of hbsag, only if you find hbvdna increase over many logs it can be considered a bad sign...many of us would like to have your little flare (not that much of a flare)

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SafiSifa

Stef and others, where are you?

I need your comments. My pshycology is terrible.

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SafiSifa

I am 29 years old and a fit body. I eat healthy foods.

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SafiSifa

Thanks a lot dear.

My treatment was going well and my motivation was getting higher until today.

For HBEAG, I only have base number (5 months ago) and 3rd month number (2 months ago). The new result will come with HBV DNA.

ALT
Before: 86 (5 months ago before treatment)
After: 90 (2 months ago - after 3 months treatment)
Now: 347 (Today - 5 months after treatment)

HBEAG
Before: 912 (5 months ago before start treatment)
After: 7.4 (2 months ago - after 3 months treatment)
Now: Not resulted yet

HBV-DNA
Before: 557 000 000 (5 months ago before treatment)
After: 55 000 (2 months ago - after 3 months treatment)
Now: Not resulted yet

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grmr

Hi safi, I'll help as I also had even worst flares during the years (ALT up to 900).

Increase of ALT means your immune systme is stronlgy fightinh hbv to get rid of that.

I'm sure DNA is further loweriing sice you are taking ETV.

This flare could lead to EAG serovnversion... are you still EAG+ve?

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SafiSifa

'It can be either host or virus induced ALT flare, so you need to understand which one you have.'

Is HBV DNA test enough to understand?

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SafiSifa

Thank you for your reply.

I am waiting for HBV DNA result. HBSAG in quantity test is not common in here. But the hospital will find a way to do the test.

'Usually ALT flare is good sign' what do you mean? Why good?

Should I take it positive according to my above results?

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