Results after 44 weeks of TDF+Peg+NTZ

[April9903]

In March 2012 (Before Treatment)
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HBV DNA --  450,897 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
HbeAg  -- Neg
AntiHbe -- Pos
Fibroscan =  4.2 Kpa
Geno Type C
Precore BCP ( T 1762 / A 1764 ) Mu
PC codon 28 Mu


22-October 2012 (After 12 weeks of PEG + TDF + NTZ )
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HBV DNA --  186 copies/ml
HBsAg (Quantitative) --  2869.70 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --61.3 ug/l
ALT - 81 u/l
AST - 89 u/l
Platelet Count is low - 140


31-December 2012 (After 24 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2606.72 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   46.1 ug/l
ALT - 52 u/l
AST - 63 u/l
Platelet Count is normal - 150
Fibroscan =  6.1 Kpa

15-May 2013 (After 44 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2612.48 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   54.8 ng/ml
ALT - 84 u/l
AST - 80 u/l
Platelet Count is normal - 177

Last week, I had the last shot of Peg. I am very disappointed with my HbsAg results. It's not going down anymore. Doc said the effect of Peg will stay on very long even after the last shot. I continue taking TDF but stopped NTZ now. My Alt and Ast is also still high. Very disappointed!

[R_2012]

You do realize that you'll still need to use Peg with Replicor right?  Provided that the drug is ever approved in current state.  

[Jeff912000]

I agree combo treatment does not increase SVR but does  not hurt.  

[mustthinkpositive]

Hi, what's your number in HBSag? Maybe IFN is good for preventing HCC because it's an immune booster. Boosting immune system naturally should have good result also but it's different for everyone. Always want to add new antioxidant to the regimen.

I feel for April.

[R_2012]

I understand the add-on to nucs, but according to Lampertico presentation in January 2013, de novo therapy with nucs and peg does not increase SVR.  As far as I can tell, he is one of the biggest proponents of using Peg initially on patients, and he does not recommend combo.  

[veteranB]

yaksss, I feel for you sorry..

Guys, you know we need to all go to Canada and sit in front or Replicor building, have them read all these stories...

That is what what we should do...

[calebz]

What's worrying is the Fibroscan result : you went from 4.1 to 6.1 within ~6 months of treatment that should help this result not worsen it from what Ive read.
You need to stay positive IFN will help despite the HBsAg result, there are studies that it lowers HCC risk a lot despite no SVR. I'm on IFN week 40 now and my HBsAg results behave similar to yours - it stays on same levels.