Story so far

[aberdeen577]

Hello Everyone,
Right now my stats are :
E antigen negarive
S antigen positive
qHBsAg 16.40 IU/ML
anti HBs <10.00 IU/ML
ALT 29
AST 24
GGT 21
ALP 37
Calcium 2.27 mmol/L
adjusted calcium 2.27 mmol/L

I am currently taking
TDF 1x245mg tablet/day (since September 2011)
Simvastatin 1x20mg tablet per day
Vitamin D3 1x5000IU tablet per day
Blueberry extract 3x60mg tablets per day
Selenium tablet (1) per day

I met with my consultant today and I am so depressed now and disappointed. He will not put me on peginf.because:
-my age
-I have severe fibrosis saying inf can cause liver damage and decompensation
-caucasion
-he has no clinical evidence that it will work with someone so low as 16IU. Says surface antigen needs to be around 500IU/ML for it to work
-it is dangerous to take
-my ALT and AST are too normal; would prefer them elevated
I feel very low now and cannot understand why he cant at least try it for a few months at least.

My question to my learned friends is what can I do now?  I would like to self medicate other oral drugs as a first line to seroconversion before inf. Stef, can you suggest a drug regime that I could look at taking? Inf looks to be a little way off for me right now. I am in N Ireland and I do not have any choice of where to go next.
Thank you.

[stef2011]

So first thing increase vitd25oh, this will bring down pth and maybe this will be enough to increase hbsab.follow the no dairies diet, no nuts, 2.5l of water daily and keep goleic gcmaf possibly nebulized weekly

[stef2011]

This is what you might do:
hbv vaccine plus aldara on the area of injection plus zadaxin this may help rise hbsab

As regards pth if correct it is out of range, max norm range is about 72pg/ml, this suppresses immune system, all pth values more than 20pg/ml might not be able to suppress th17 which is correlated to weaker hbv responses and autoimmunity.try to rise vitd25oh to 150ng/ml and see if pth goes down

For example when my vitd25oh is less than 100ng/ml i have pth over 106pg/ml and no response on hbsag.

[aberdeen577]

Nagalase not checked yet because there in no one now in N Ireland who can do this. I think Dublin is a possibility but I am going to have to go there to get it done. Will organise soon.

[aberdeen577]

I got my results in the post yesterday. My fibroscan was 10.5, up from 6.5 the previous year. I asked them to do it again and they did a few days later, it was 7.2 the second time. The prof told me that the nurse was probably hitting a bad localised piece of liver hence the different readings. But I am not sure on this.
Surface antigen NOT detected
Surface antibody <10IU therefore non immune
PTH 4.0 pmol/L equal to 84 pg/mL ( if I worked it out correctly)
Vit D3 is 293 equal to 117 ng/ml
AST is 25
ALP is 47
ALT is 24 Bilruben is 16.8
GGT is 18
Calcium is 2.40
Creatinine is 84

[sundaram340]

what is ur present status?

[aberdeen577]

Thanks Stef, yes I need to get nagalase checked again. It was originally 2.2 before I started stabilised vit D.