it all depends on your hbsag quantity in serum
etv and tdf may be used anywy for this combo because your hbvdna is never zero in the liver but if hbsag is very low even interferon alone will reach clearance, hbsg less than 1000 and less than 500iu/ml have highest chances.
my opinion is to use the combos anyway, intf+alinia or intf+tdf
of course as StephenCastlecrag expert doc is needed, intf is not piece of cake
We have had some "unscientific" discussions about this: after undetectable hbv dna:
1. Stop the antiviral medication, wait for a flare, then see if you clear the virus. There is a clinical trial using this strategy.
2. Use Interferon. In this case, I would use qHbsAg to monitor progress.
In either case, you will need to be under the care of a bold and experienced doctor, in my humble opinion.