my hepb history. hbsag sero conversion

[fcar1]

Hello all,

I'm 32 and I was diagnosed with hepb in 2012 in Brasil.
In the first months I was not going under any treatment because my doctor didnt know if it was acute or chronic,
so we were just following it with exams.

Below you can see the first results:
05/2012
ALT - 184 U/L
AST - 102 U/L
HBsAg pos, HBeAg pos, A-Hbe neg
HBV Quant - 958.314.180 UI/mL

06/2012
ALT - 1244 U/L
AST - 398 U/L
HBsAg pos, HBeAg pos, A-Hbe neg

08/2012
ALT - 467 U/L
AST - 161 U/L
HBsAg pos, HBeAg pos, A-Hbe neg
HBV Quant - 60.975.743 UI/mL


I was supposed to start a treatment in the end of 2012, but I got a job offer from Czech republic and decided to move.

In the beginning of 2013 I found one doctor to help me here in Prague, she first prescribed Baraclude 1mg.

04/2013
AST 1.09 ukat/l
ALT 2.42 ukat/l
HBsAg pos, HBeAg pos, antiHBe neg
HBV DNA PCR quantity 4x 10/8

07/2013
AST 0.88 ukat/l
ALT 2.17 ukat/l
HBV-DNA-QPCR (IU/ml)..... 3,61e4 IU/ml

11/2013
AST 1.17
ALT 3.3
HBsAG pos, HBeAg pos
HBV-DNA-QPCR 8.6x10/3

In january 2014 I had another exam (dont have the values) and my doctor decided to change the treatment to Viread
(she tought Baraclude was not helping the way she wanted).

I did few exams after but I don't have all the details.

On March/2014, she told me that my liver tests were normal, viral load was low HBeAg was negative and A-HBe was positive.
June/2014 did another exam and got this email from her:
"HBV DNA viral load is still negative.
But the main thing ... :-) HBsAg is negative. So it looks like we could stop treatment for a year."

And from my last exam I have this info:

09/2014
AST 0.45 ukat/l
ALT 0.29 ukat/l
HBsAg neg, HBeAg neg, antiHBe pos, antiHBs neg
HBV-DNA-QPCR (IU/ml)..... 0


I would like to hear your opinion about this, what does really mean having HBsAg neg and viral load 0?
My doctor is czech and she always tells me few about the results.

What she told me now is that for her I'm healthy, but I should continue with Viread till June next year, or till I get antiHBs positive.

[SafiSifa]

Congratulations.

I am also cured with Baraclude in only 12 months.

Although I am totally cured, I am still on Baraclude treatment.

See my results: http://www.medhelp.org/posts/Hepatitis-B/My-All-Test-Result-After-12-Months-Treatment-of-Entecavir-I-am-cured/show/2355051

See my story: http://www.medhelp.org/posts/Hepatitis-B/Urgent-Advise-for-Entecavir-Usage/show/2044528
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[mustthinkpositive]

Congratulations. You have developed surface antibodies.

Your HBV Quant will be undetectable/negative so there will be no numbers. Your Dr will decide on whether to stop treatment which I would suggest pretty soon.

[fcar1]

@stef
Can't say, my previous exam was on 09/2014 and antiHBs was negative.

@sorte
chronic and I have no idea for how many years...

[sorte]

Do you know if it was accute or chronic and how many years you had it ? Did you had ever tested AntyHBc - Total ? I think it would help to differ those types of infection cuz for chronic it may stay positive for years.
Not sure what happens with those antibodies after serovonversion or recovering after accute, anyone ?

[stef2011]

is it 6months since hbsab>10miu/ml?

if so it is safe to stop antiviral but to be on the safe side test hbsab every month and if it declines too much restart tdf

[fcar1]

Hey guys,

I just wanted to update you with my last exams (I still don't have the HBV quant. results).

06/03/2015
ALT - 15 U/L 
AST - 20 U/L 
HBsAg neg, HBeAg neg, A-Hbe neg
AntiHbs pos - 315 UI/L

It seems quite good results, do you think I can ask my doctor to stop taking medicine with this level of anti-HBS?