Aa
Incivek duration?
Has anybody stayed on Incivek longer than 12 weeks? If so, what were results?
I am Geno Type 1a Hep C foe 30 yrs. VL 11.4 at start of treatment. VL 470 @ 27 days after first shot.
Little sx so far. Tired, shortness of breath, slight rash. All manageble so far.
I am Geno Type 1a Hep C foe 30 yrs. VL 11.4 at start of treatment. VL 470 @ 27 days after first shot.
Little sx so far. Tired, shortness of breath, slight rash. All manageble so far.
Best Answer
You are only beginning this treatment. I predict that by the time you get to week 10 you will no longer even consider taking the Incivek longer than 12 weeks. Besides, the risk of adverse events increases dramatically beyond 12 weeks. The rash can get really really nasty and if it gets systemic, which happened a lot more often past 12 weeks, you could end up with SJS or DRESS and you DO not want to go there! Please discard this idea now!
Like the others said risk & cost outweigh the benefit.The PI's main purpose is to kill the virus fast. Usually within days. At 12 weeks the PI hopefully has kept the virus dead. Then the SOC drugs riba & inf finish the job to achieve SVR.
Back in the trials I believe Andiamo did 24 weeks or near to. He got to SVR.
But I agree with what the others have said, 12 weeks is plenty.
dointime
But I agree with what the others have said, 12 weeks is plenty.
dointime
Some of the early trials, that were conducted in Europe, went beyond 12 weeks. I don't remember exactly how long or the specifics right now but I can tell you that the rash became a VERY significant issue and almost kept the drug from getting to market. There were some cases of Steven Johnson Syndrome and DRESS that were horrible to read about. Eventually, they learned how to manage the rash better, and they shortened the treatment to 12 weeks. (At first they treated the rash like it was a pro tease inhibitor rash, similar to the ones AIDS patients on treatment get. The treatments didn't work and may have made the rash worse. Eventually they learned that plain antihistamines worked much better.) The shortened treatment and the antihistamines, made the treatment safe enough to pursue.
Yes, I've been taking it since the beginning and monitoring it. Bloodwork Monday and i'll see where it's at.
One thing to have checked if you haven't already considered is your Vitamin D level. I had mine checked after reading on this forum and learned that I was deficient. There are several positive benefits to taking Vitamin D if your levels need to be supplemented.
http://www.hivandhepatitis.com/2010_conference/easl/docs/0518_2010_b.html
www.viraled.com/modules/info/files/files_4dbeda6600d27.pdf
http://www.hivandhepatitis.com/2010_conference/easl/docs/0518_2010_b.html
www.viraled.com/modules/info/files/files_4dbeda6600d27.pdf
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