Just as I thought,relapse

[GP7852]

It was too good to be true-finally after doing every study known to mankind since the 80s and I mean a shot of 3 million interferon everyday,and then on to the 5 million everyday and when that failed it was 10 million everyday.And everything else that came after with failure after failure.And finally sovaldi and olysio come along and I finally find a hero,finally negative and just in the nick of time.Geno 1a-stage 4 cirrhosis complete with every possible side effect that makes me want to say the hell with it sometimes.Today I go and get my 1 month after Tx bloodwork and the first thing I see is Hepatitis C quantitation 694,770.Ast and Alt ballooned from normal range to 200 and 159.I had to sit down on the bench outside the office,no way I could drive cause I had no legs.I had a feeling something was wrong because I was so itchy and still having leg cramps but I hoped it was the cirrhosis.Naturally my docs first available was in two months so once again its back to the drawing board.The lady who takes my blood told me she had two yesterday on the same treatment that also relapsed.I just cant believe or accept the amount of Hell you go through only to end up on a treadmill that takes you nowhere.
                                        Good luck to you all     Glen

[pooh55811]

And All:

Here is another quote from Dr. Sulkowski (Clinical Care Options) concerning the new drugs yet to be released:

"The Coming Wave of All-Oral DAA Therapy
The data are crystal clear: For previous null responders with cirrhosis and perhaps for treatment-naive cirrhotic patients too, the best chance for a potentially life-saving HCV cure is an oral combination regimen of potent DAAs. By the end of 2014, we expect the FDA approval of the first agents in a new class of HCV DAAs called NS5A inhibitors. These agents will be an important part of 2 potent, interferon-free, all-oral regimens: the once-daily, single tablet, fixed-dose combination of sofosbuvir/ledipasvir and a 3-drug regimen that includes a fixed-dose combination of a ritonavir-boosted HCV protease inhibitor (ABT-450) plus ombitasvir (an NS5A inhibitor) administered with dasabuvir (a nonnucleoside polymerase inhibitor). The New England Journal of Medicine has published results from a series of historic phase III studies, also presented at the 2014 EASL annual meeting, in which HCV cure rates were between 82% and 100% across treated and untreated genotype 1 HCV–infected cirrhotic patients receiving these novel regimens with or without ribavirin. Some fine-tuning of therapy may still be needed in this group of patients."

[GP7852]

Thank you for that info-I have written down your information and I am going to talk to my doc about it when I see him in August.I do love the part about no side effects,I have had enough of them for one lifetime.
                             Good Luck   Glen

[Verdugo]

Glen, everyone on this forum feels your pain, either thru empathy or sympathy.  Your loss is our loss.  

Altho everyone may be on a different combo of meds, the common denominator is Sovaldi.  It's been touted as the miracle drug but as we are seeing, sadly it may have been misrepresented and/or hyped.  I'm very sorry these meds failed you but there's more to come for you soon.

Try to get out and enjoy the summer and reset for your next attack!

[GP7852]

Thank you Kim for your kind words
I remember thinking throughout treatment with s&o that how can this work?I am not suffering enough.I was so used to the flu like symptoms and the anemia that I had this inner belief that you must suffer for the meds to work and the fact that I wasn't suffering made me think this stuff wont work.Can it be easy and still work?
                       Thanks again Kim      Glen

[GP7852]

Thanks for the encouraging words Hector
Hopefully a new fight will be fought before the end of the year.I wish you all the best with your new liver and your next brawl as well.May we both get better,feel great and live to triple digits.
                  Best of luck     Glen

[penn1023]

Talked to my doc today and he told me all the S/O failures he is seeing is with 1a's .. They are adding Riba to any new S/O people after testing for Q polymorph..
Are any people who failed S/O 1b's?