I've always been influenced in my thinking on this subject because back when Joe was sick and getting sicker, he had a very high viral load in the hundreds of millions. I don't often see people post those really high numbers but that is where Joe started. Since using HR's supplements, it has so far, never been that high again but we were approximately 3 years and 2 failed TX down the road before we found HR's supplements. His viral load has been staying in the 1 millions. I know this is only data from 1 person and it is also a person with cirrhosis but that is our experience and I can just share it for what it is worth. Joe isn't as sick as when we first began by any apparent sign. I don't want to be argumentative at all. I just want to share information peacefully. Maybe Joe's case is just a fluke. He still has cirrhosis, but he is stable and feeling decent most days.
I promised myself not to stay on here all day because my laundry room is getting scary. I need to put all my attention to knocking out a few laundry virons today :>)
Best regards,
Ev
Thanks for letting me know I can relax on that score.
What I'm saying is........
Viral load does not indicate how much damage is
being done to the liver. It does not indicate the progression
of fibrosis or cirrhosis as I tried to explain above.
Have a good day and try to relax
very often with a spike in viral load we also see ALTs go up indicating more ongoing
cell damage.When on tx we usually see big improvement of ALTs with the rapid drop of
viral load even when still detectable.
Viral load has no meaning for over time accumulated liver damage (scarring)
since viral load can vary greatly during that process.
I think we can all agree the less copies of virus to be found the better with the ultimate
goal to be and stay UND forever.
I haven't seen a single comment from anyone in this thread that says they believe that viral load equates with level of liver damage. The first poster mentioned bringing down viral load but did not state why this is important to her/him, the next poster made the tie-in to liver damage.
Subsequent comments were speculating on the possibility that viral load can potentially cause some damage in general and also the speculation that there is more to be known on whether it contributes to fibrosis - one person's opinion that they'd like to see more data and other people saying they are sufficiently satisfied there is no connection. I don't see any issue with those opinions. I have not seen anybody firmly stating there is a connection but rather stating firmly there is none.
Subsequent comments are related to the concept that the impact of viral load in general needs further exploration.
I haven't seen anyone in this thread saying that viral load is a predictor of liver damage. I think you can relax on that score.
Please, someone please, enlighten me.
Then why did my son pass away? if some say
the viral load is so significant. Wouldn't that serve as a marker
to determine how damaged the liver is/was?
Low viral load.....I'm saying 2 mil....and steady.
They only did viral load during TX...three times non-responder.
Then on maintenance therapy. Viral load still at 2 mil.
All the while the liver was being damaged
They never used the viral load to determine liver damage, not once.
They used various labs, and MELD when the liver was
decompensated. Two biopsies only. 1st one showed 1-2
next one, five years later 3-4...
I was informed time and time again the viral load has no bearing
on the amount of liver damage.
They used the viral load during tx only.
I can't believe the viral load is a predictor of liver damage.
I just can't.
From Cory's link:
http://www.hivandhepatitis.com/hep_c/news/2011/0201_2011_a.html
"Elevated serum HCV RNA level was associated with an increased risk of cerebrovascular death, suggesting that individuals with an active HCV infection may trigger a stronger inflammation response by host-virus interaction leading to atherothrombosis," they continued. "Whether patients with persistent HCV infection had increased circulating levels of inflammation markers such as C-reactive protein or endothelial progenitor cells may provide insights on the mechanisms of HCV infection and cerebrovascular disease."
Since we know that HCV contributes to a number of extra-hepatic illnesses, we know that viral load causes damage. Does elevated viral load cause more damage? Has there been enough targeted study to know? This article Cory posted indicated that elevated viral load has an impact on this at least, it's not a stretch to think it may cause other issues as well, however it remains to be substantiated. I think it's more reasonable to say there have been insufficient studies on it to conclude one way or the other rather than simply deciding there is or isn't harm and propogating that, with insufficient data to back that up.
Perhaps there is other data similar to what Cory has posted and reasons why experienced doctors are monitoring viral load on patients with HCV.