melatonin as an antifibrotic

[merryBe]

I don't know when I first read of Melatonin's benefits to the liver.
It was about when HR was explaining liver funtions that I went reading and discovered that the reason HCV people didn't sleep well was due to not enough HGH from the pituitary and not enough melatonin from the liver whih leads to poor sleep, tongue swelling and sleep apneas.
Anyway I was already on HGH and added melatonin to my regime.

However, here' another study suggesting that melatonin is an antioxidant and reduced fibrosis and several key oxidative markers in rats. Ergo it should help us as well.....with more than just sleep.

apologies if someone already posted this study, I've not been around much lately.

http://www.wjgnet.com/1007-9327/15/1452.asp

[merryBe]

yeah I did think that was high, I don't get why so many studies use such weird doses, I guess to see the max effet... and the NAC also, it's sulfer and too much of that becomes an issue.

My dose is 1 mg.  too muh, or time release has issues, but I think it's one thing we could safely add that would help the sleep and the fibrosis...plus the liver makes it anyway, just less when we have this disease...so we are just are adjusting really for what our aging organs can no loger make.  : )

good to see you DAD !

mb

[GoofyDad]

Thanks for posting that. Did ya notice the dosing? MEL = 10mg/kg. Normal human dose is what, about 5 mg? That would be like 750 mg instead of 5mg!

I had difficulty parsing out the benefits if any found from NAC - I think it's in there somewhere. NAC dosage was a whopping 100 mg/kg. For me that would be close to eight grams. Yowzah!!