I have severe pain from spine and joint inflammation, and severe arthritis. As well.as much vertebrae damage.I have been taking minocycline orally, but can't afford I.v.therapy right now.I have been on minocycline for two years, but have also been on prednisone, I recently read prednisone will keep antibiotic from working like it should.please, if anyone has gotten any pain relief and is as damaged as I am, please let me know.I am also on a pain patch and pain pills, as well as plaquenil, because I test positive for lupus.I am in Ned most of the time, and am still in horrifying pain! When I do get up and play with my grandkids, I suffer for days from the activity.I know I shouldn't complain, and that there are ppl with far worse conditions, especially children, but I got on this site hoping to find help.thank you kindly for your help, and fyi.if I ever get better, I will do all I can for others in my condition, I am a 57yr.old wife, mother,and gammy!