Any updates?I think patm is because of liver.A analysed all data and conducted tests mysel.A new study 2023 by Sekine From Japan says that a typical phenomen in PATM patients is toluene accumulation.This is because lack of metilation.Toluene is absorbed and coverted into phenol in the liver by p450 citocromes.Then it is converted 2 more times before going to kidneys to be aliminated.As it seems,the liver is not transforming the toluene into phenol to be eliminated so the metilation is not working.I tested with OAT and my metilation is very low 0.25 range being 1.5-4.I also had mitocondria and fatty acid oxidation problems and some detox acid being very low.Also another acid glucaric i think showing the p450 activity was low.I think all these shows its a liver problem.I dont know if its because of mold exposure or sibo sifo leaky gut.Do you have any updates?
Actually what you don't understand is that PATM is not the same thing for all the people who have it.There are about 5 types -undemethylation,overmethylation,pyrrole disorder,copper overload,heavy metal toxins overload.Treatment is individual.That is why one thing works for some people but for others don't.Learn more about methylation cycle.Balanced methylation is what we need for good health.