I was diagnosed with sever depression and anxiety about a year and a half ago directly after spine surgery. I took Lexapro for a while increased dosage twice then added Seroquil and increased its dosage 3 times. After a few months gaining all the weight I had lost back(nearly 40 pounds) I tapered off all the meds. I have recently had knee surgery and a Gel One injection. I thought my health problems were behind me. Two months later I find myself nervous all the time. I have restless nights not being able to stay asleep. I started back smoking. I find myself unable to relax without drinking too much. I have aches and pains all over. I am week. I have lost about 30 pounds again. I feel anxious and irritable all the time. My hands are shaky. My mind and heart races at times. I am having some panic attacks, although not as frequently as I used to. My wife was very helpful the first time I was battling this and pain pill dependence. This time she seems distant and depressed herself. I am under a great deal of work and family stress. Those two stresses are intertwined as we are in family business. I really don't want to get back on meds but willing to try anything. Any ideas?