Thankyou but i really have questions regarding this
If someone is ltnp or elite controller will this test be still conclusive after 4 weeks ?
What about those with delayed seronegatives ? Still conclusive ?
Simple answer to your original question, is the 4th generation Duo really accurate at 28 days. Yes. Your risk was there but low with a one time encounter. You tested negative at 30 days. I'd consider yourself negative in a conclusive way and relax/move on. That's the bottom line.
https://www.gov.uk/government/publications/time-period-for-hiv-testing-position-statement
Please read it, this document is available on official website of Government of UK.
Do not include yourself in one out of a million case where positive reported after so many days. You do not know the details of that particular case, his status of immune system health etc.
Medical research papers are written in a different perspective. Your 4th generation Duo test is highly sensitive and reliable, catches virus protein and as well as antibodies, therefore it is more accurate in the early days as compared to its predecessor.
CDC, though have not issues revised guideline but does states that the test gives reliable results 3-4 weeks earlier than 3rd generation test. And you know, these authorities are extremely careful in making any statement
The site you referred to did not mention the reason for this phenomenon. I can tell you why, you go read yourself, i will write a journal about this when i am free.
1) non clade b hiv virus
2) Hypogammaglobulinemia
The reason why this is confusing to you is it is written for medical professionals of which I'm guessing you are not. It's like reading a law document with the jargon meant for other lawyers. Almost like their own language Experts agree that 28 days is the right time frame for the 4th gen duo test to give a result but anxiety makes people not want to believe that or accept that. We all have to accept it and understand anxiety is normal until it's not and making us worry more than we need to. If you get what I'm saying.
http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/BloodDonorScreening/InfectiousDisease/UCM216309.pdf