After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[studyforhope]

You should not have any relevant side effects from the vaccine. The zadaxin will be a potent enhancer of the effect on AB levels.

[studyforhope]

If you can afford it, then the monthly dosing of tne vaccine until your AB TITER is above 200mU is the better way. Don't worry about the standardized timing of vaccine shots. There is no deep immunological reason behind this timing, it is the way the vaccine was approved for prophylactic purposes.

[stef2011]

no, no sides at all i guess, studyforhope might confirm

there are 2 studies on making monthly hbv vaccine in rome and turin, this was few years ago.
after liver transplant many lose hbsag by hbig+nuc, so in those centers they lowered immune suppressive dose and used monthly hbv vaccine to see any hbsab could develop on these patients to stop hbig, i dont remember exact percentage but it was extremely high of patients develpping hbsab in a good titer so they could stop hbig

so in the end i think monthly hbv vaccine plus tenofovir plus zadaxin is a good choice keeping high normal blood values of vit d3 (around 80ng/ml)

[Otan]

Steff,
I will take tenofovir plus zadaxin.

About vaccine,
2nd dose is a month after the 1st
3rd dose will be 5 months after the 2nd
What about the 4th dose time gap from the 3rd ?
Is there any sides from extra dose of vaccine?

[Otan]

Thanks Imran...

[stef2011]

i d go for tenofovir, more potent, no possibility of resistance at all, cheaper, one pill per day