After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[imran4535]

TDF = Tenofovir, daily dose is is 300mg

ETV = Entevavir, daily does is .5mg

[Otan]

Stef,

(zadaxin plus tdf or etv)

What is tdf or etv fullform

And what is the dose of entecavir? 1 per day?

[Otan]

Steff and studyfhp
Thanks a lot...
I will find a doctor that can prescribe me this. Sometime is not easy to ask doctor to prescribe what we want.
Thanks again to make me more carefull about my heps, I thought it was OK after I have Antibody.

[studyforhope]

Zadaxin was indeed shown to clearly improve vaccination response. It can be taken before at the same time or for several  weeks after the vaccination , which seems best. The vaning AB titer is a sign of a lack of a T helper response and could also mean that you could overall loose your Tcell control over the remaining virus, that always lingers in the liver, unfortunately.

I also agree, that adding tenofovir for at least as long until you feel safe with the seroconversion stability is a wise precaution, as Stefano mentioned. I would start for a year and see if the antibody level can be stimulated with the help of zadaxin.

That's about all you can do besides living a very healthy life style and watching your vit d levels.

[stef2011]

to otan and studyforhope:

waiting for studyforhope response i guess you do need to keep hbsab higher than just around 10miu/ml, maybe keep entecavir or tenofovir for a long time plus repeted dose of vaccine

pisa researchers told me that in case of serocoversion hbsag neg and hbsab detactable they keep antivirals for about 1 year and if needed use hbv vaccine at the same time (even more than 3 doses) until hbsab is good levels

studyforhope knows for sure what to do, maybe use of zadaxin plus tdf or etv and repeted hbv vaccine until hbsab gets high enough

[Otan]

Dear Studyforhope,
I have finish the 2nd dose of vaccine but no HBS Ab increased.
My GOT/GPT are normal now. Should I take the 3rd dose on June 2013?
With this condition of HBSAb keep decreasing, is it safe from Heps B recurrent?
Thanks for help...

6/7/12 38 dose interferron
12/7/12 SGOT-93 SGPT-142; HBSAG- <0.05 iu/ml; HBSAB-negtv
17/7/12 Start taking Baraclude 0.5mg, 1 tablet per day
20/7/12 40th dose intrfn
25/7/12  GOT-108 SGPT-171
15/8/12  Last Baraclude taken
15/8/12  SGOT 117 SGPT 207; HbsAg- not reactive
24/8/12  HBSAB- 70 mIU/mL
14/9/12  48th dose intrfrn
19/9/12  SGOT-102 SGPT-162; HBV DNA- undetct; HBSAG quanty-
<0.05iu/ml; HBSAB- 122.58mIU/mL
16/10/12  SGOT-88 SGPT-165; HBSAB- 107.13 mIU/mL

6/12/12 SGOT- 34 SGPT-53; HBSAg- non reactive; HBsAb-71.43
10/12/12 Took 1st dose vaccine of Engerix TM-B Adulta dose, r-DNA 1ml HBsAg 20 ug

8/1/13 SGOT-27 SGPT-45; HBSAg-non reactive; HBSAb-52.88
10/1/13 Took 2nd dose of vaccine
22/1/13 HBSAb-43.2
18/2/13 SGOT-25 SGPT-40; HBSAg-non reactive; HBSAb-15.1