Side effects of therapy

[Vireadeater]

Hi there,

I would like to discuss my Viread "side effects" with you. But first some relevant data.
Got diagnosed with Chronic Hep B in March 2011:

- Hbeag Negative
- Genotype D
- Grading 0-1
- Male

Started Viread (Tenofovir) in April:

- HBV DNA in April: 29.000
- HBV DNA in May: 45
- HBV DNA in August: Undetectable
- Hbsag in August: 30.000 (First time it got measured.)

So far so good, but here comes the "strange" data:

- ALT in April and before: Between 65 and 73
- ALT in  May after I started Viread: 93
- ALT in August: 93

Besides I have some "side effects" since I have been taking Viread that one could sum up as the typical symptoms of acute hepatitis b OR the side effects under Interferon:

- Pain over the location of the liver (on the right side of the abdomen, under the lower rib cage). I never experienced that before taking Viread
- Flu like symptoms: Muscle aches; Headache, Temperature, Tiredness. They come and go. Again I did not experience that before.

My doctor says this COULD be some immune reaction but wants to wait for the next results in November. Because she was also a bit surprised by the rise of my ALT since she figured it should have rather dropped considering the decrease of my HBV DNA.

Any ideas out there? Anyone who experienced something like that in therapy? Would be glad to hear your thoughts and opinions. And thanks for this community here!

Keep it up!

[Vireadeater]

Thanks fyou guys!

The next HBSAG count will be in Febuary.

Concerning the fatty liver when I had my biopsy in April they found out that I have minimal steatosis. Even though its not much it surprised me anyway cuz I am not a fat person at all and I am doing lots of sports.
Any suggestions what else to do to get rid of all of the fat in my liver?

[stef2011]

did you find if there was any fatty liver involved too?

are you following hbsag in iu/ml (this is the most important thing) because if it reaches 1500-2000iu/ml you can try clear with interferon with higest chances of success

also abnormal alt with no fatty liver and hbvdna und can be some clearance of hbsag already

[enolia]

Good for you! Any news about your HBsAg count?

[Vireadeater]

Hello everybody,

just to keep this updated:

HBVDNA still undetectable
GPT also dropped from 93 to 70
The above mentioned sides got also less

I am quite happy so far.

So long, all the best to you guys!

[4est]

Maybe a separate thread will be a good thing to do.  
Also consider to will include all the tests results and treatments in a chronological order and also you will update that thread with new tests like HBsAg and also all test after alinia combo.

just a suggestion :)

[joc2011]

Hi Everyone. Just had my LFT test results today. SGPT (ALT): 9 and SGOT (AST): 15. Still on Viread for the next 6 months. About to start combo with Alinia. Will also quantify HBSAG asap and will post results.