Hey aberdeen577, why don't you try the Heptech products to reverse your fibrosis?
What about NTZ? Good luck to you sir. It looks from your figures you are in great shape other that your fibrosis.
first of all this doctor said too many lies or wrong things if he is so stupid.......
what was your baseline hbsag?16iu/ml is such a low hbsag quantity could it be sim and d3 to make it so low?or maybe you started with such a low baseline hbsag?
what is your fibroscan?severe fibrosis is way over 16kpa and it is not true pegintf cannot be used on cirrhosis and that it can make decompensation, a stupid doctor not able to deal with that might make damage but not intf itself if correctly managed and anyway you ll never decompensate because being hbvdna und and alt normal pegintf and with so little infected cells left with hbsag 16iu/ml cannot make very high flares
please post your fibrosis on latest fibroscan and if you like you can reverse it very fast like a did on gcmaf plus heptech, probably a period like 6-12 months
it would be also interesting to see if gcmaf is able to clear hbv when infected cells are so low and hbsag so low, i guess it could work to clear hbv on you
Can inject double dose vaccine once a month for 3 month to boost the HBASG level and get response from PEG interferon. PEG interferon can be use in cirrhosis as Steff saids.
Actually you are very well read. Hep B patients are often low on selenium and Vit D3. Your HBSAG is low probably due to cirrhosis. could be due you killing infected cell. PEG may help rid the last little bit of HBSag.
57% patient can reverse cirrhosis just on tenofovir for 5 years. Maybe if you add heptech it may be faster.
i d try gcmaf ahead of heptech, it may have double effect on both hbsag and fibrosis and if it works it will show results in few weeks if it does not you can go to heptech which is sure to work but slower
also alinia might work on such low level and hbv vaccine plus zadaxin too
you have many choices before trying peg
Stef, in may 2011 my fibroscan was 11.7 kpa followed by biopsy which indicated f3/4 fibrosis. In november 2012 i had fibroscan in London and it was 8.7 kpa. I will have another one again in London in November coming. I am prepared to try drugs myself w/out resorting to inf at this stage.
Do you have other qHbsag tests? Your hbsag is very low and only a few are lucky to have such a low one. Make sure this value is already diluted otherwise you have to multiply usually by 500. But if you have such low hbsag values confirmed from other labs then there is surely no doubt you are in the low range.
Hi Jeff,
What is your status on Hep B. Are you an active or inactive carrier? And what is your current regime/treatment? Looking forward to your response.
My hep b is active. My treatment is bit of whatever is discuss in this forum. But usually whatever I get my hands on locally. however I tried some stuff like reishi mushroom and it has no effect. Steff has incredible insight into the hep B and i usually read his insight to gain further understanding.
To Aberdeen.. Please check your genotype as well.
To Steff. Aberdeen's doctor has a new insight. Some people with very low HBSAG is actually not going to respond to interferon. That is why i suggested adding vaccine. I wonder why this is so.
Aberdeen's doctor saids it is better to have high hbsag at 500hbasg iu/ml. it is also better to have more damage as reflected by ALT before starting PEG.
To Steff. Aberdeen's doctor has a new insight. Some people with very low HBSAG is actually not going to respond to interferon. That is why i suggested adding vaccine. I wonder why this is so.
no this is not correct the lower the hbsag the higher the chance to clear, he has already the immune system clearing hbsag so adding pegintf plus sim or trying gcmaf plus zadaxin and hbv vaccine all might work
as to your biopsy results and fibroscan you had no cirrhosis and the values were not hgih to justify not using pegintf.the only thing a doctor might say is with such low hbsag you are probably clearing anyway, let s follow how hbsag goes down and then we will choose if adding pegintf, on the contrary what he said is wrong
anyway 8.7kpa is a good value and gcmaf might lowering to normal in few weeks if the theory of stemcells is correct.are you normal bmi or overweight?
Aberdeen's doctor saids it is better to have high hbsag at 500hbasg iu/ml. it is also better to have more damage as reflected by ALT before starting PEG.
that s all wrong that was a very old view on intf and it is even worst on nucs, that doctors understands nothing about hbv and pegintf just follow guidelines, old guidelines, without no clue about the way immune system/hbv/pegintf work
to sum up you can:
try gcmaf for 2-3 months and see how hbsag and fibroscan changes (gcmaf requires vitd>50ng/ml and oliv oil in the diet which increases oleic acid in blood)
start pegintf add on plus sim with normal blood levels of vit d
look for an expert and very updated liver specialist on nucs and peg add on, there are other members in uk that found very expert liver specialist who partecipate in making hbv uk guidelines, i can t find the name of this doctor in my emails, hopefully the member will post his name
then what is your theory about some patient with very low HBSAG but interferon cannot even move it.
low HBSAG could be due cirrhosis (not many infected cells left), patient already killing cells or poor secrection of HBSAG. In the last cause, only a biopsy with hbsag staining can demonstrate how much surface antigen is present inside the liver cells.
Cirrshosis could also be due to other causes likle alcohol or drugs superimposed on HEp B. Only people who are already killing HBSAG infected cells amy repsonce to PEG.
So a low HBSag may not mean the person is killing infected cells. PEG may still not work.
Another theory is the person needs immune recovery by tenofovir for 3 years to get better interferon response.
TO Abeerdenn, fibroscan is not good in fat people. Does your US scan should nodular surface or hepatic vein outline. This would support fibrosis. if the US is normal. The fibroscan is wrong. what is your platelet count? What is your BMI?
The doctor you speak of is dr kennedy, i think aberdeen knows about this doctor
i havent seen any study or percentage on patients with hbsag level around 10-20iu/ml not responding to pegintf, on the contrary studies report hbsag clearance when reaching 10iu/ml or less at 48weeks treatment
http://www.ncbi.nlm.nih.gov/pubmed/19338056
another way of clearing is stopping all therapies at such low hbsag, the study on tdf showed clearance of hbsag, but this is too dangerous and yet too small reposrts
i think the best try is again gcmaf and hbv vaccine plus zadaxin or even better the israel hbv vaccine with imiquimod used on the area of injection but this would require to go to israel to buy it
This reminds me. Does the yogurt form of GCMAF work? I would like to learn and get it. The japan one is actually like tranfusion. They harvest it from young healthy individuals.
Thank you for your kind comments. Yes my surface antigen is low and I hope that this with the lower level of fibrosis will lessen my risk of HCC.
HAve had it done twice at the London clinic. First time on November 2012 it was 12.80 IU/ML. In March of this year it was 16.40 IU/ML. Will have it done again in November along with a fibroscan. I am sure that a place like this would be presenting me with correct figures, I sincerely hope so anyway.
To Aberdeen.. Please check your genotype as well.
I will in November, have not had this test done before.
let s follow how hbsag goes down and then we will choose if adding pegintf, on the contrary what he said is wrong
Will go to London again in a few months time and have fibroscan, surface antigen test and genotype test. Then we can decide the next step Stef. I will of course try the gcmaf as a first line to get rid or remaining virus.
anyway 8.7kpa is a good value and gcmaf might lowering to normal in few weeks if the theory of stemcells is correct.are you normal bmi or overweight
I have 185 cm height, 89kg weight and size 34 (UK) waist.
TO Abeerdenn, fibroscan is not good in fat people. Does your US scan should nodular surface or hepatic vein outline. This would support fibrosis. if the US is normal. The fibroscan is wrong. what is your platelet count? What is your BMI
US scan shows normal liver in every way and my spleen is also ok and portal vain. No fibrosis can be seen in US. IN fact the nurse said that had I not told her that I had fibrosis she would have said to me that I had a perfect liver.
Also, I have 185 cm in height and 89 kg weight.
Your BMI is 26. Your overweight. Fibroscan is not accuarate in fat people. Loose lots of weight and do steff's cirrhosis reversal regime. Try fibroscan again afterwards.or do biopsy for accuarate assessment.
the yogurt type and the injection type of gcmaf are not exactly the same thing overall since gcmaf activates vdr and vdr has so many genes and pathways under control, while if we consider it as a macropahge activator the products can be considered the same
they work this way, gcmaf is made from blood and enginered a step ahead of nagalase so the nagalase made by virus/bacteria and cancer cells cannot inactivate this injected gcmaf.our own gcmaf is of course inactivated by nagalase
gcmaf probiotic contains gcmaf but it does not enter blood stream, it just activates macrophages in the malt, macrophages when activated go after the source of nagalase and clear it so that nagalase goes down and your own gcmaf can work again
they are similar in the endpoint but as you can see not the same, i also guess that the probioctic cannot activate stemcells until the nagalase is not lowered to normal levels and your own gcmaf can then activate your stemcells
I prefer not having to inject or use other people's blood product if possible. So is probiotic GCMAF synthetic or from blood products? Does probiotic GCMAF work?