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Thyroglobulin Antibody

Hi,

Below of the test results that I recently got. This test is done on Jul 27. I was on levothyroxine 75mg for two months from Apr 20th to Jun 20th. So, by the time this test is done, I guess the medication might be out of my system.

TSH: 3.110 UIU/ML

Free T4: 0.91 NG/DL

Free T3: 2.4 PG/ML

Thyroglobulin antibody: 2.3 IU/ML (Report says this is high)

TPO ab: 11 IU/ML

Now, I was asked by my provider to take 50mg of levothyroxine.

So, my question is if i take thyroid medication again  for TgAb, even though my TSH, T3, T4 levels are normal, doesn't it elevate my thyroid levels? I have my lab scheduled again on sep 17.
What are thyroid antibodies and what is its role in thyroid? Can you point out to some material where i can get the information?


This discussion is related to Test Results .
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Avatar universal
The below are my lab reults for reference after using 75mg for 8 weeks.

Free T4: 2.66 NG/DL

Free T3: 4.7 PG/ML

TSH: 0.01 UIU/ML
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2 Comments
Physicians test Thyroglobulin for those with ThyCA. This test shows a trend going up or down, which indicates if your cancer may be returning. Testing Tg when a patient does not have thyCA, the Tg test is basically useless.
Forgot to add that when a patient may have thyCA, most labs (especially your TSH) show as Euthyroid, or normal lab values. This is why a neck exam and especially an Ultrasound (and/or a Fine Needle Aspiration) is imperative when nodules are felt, or found when doing an unrelated CT scan for another issue. Labs many times lead a doctor to the conclusion that your thyroid is functioning normally, it truly comes down to HOW you FEEL and any symptoms or palpated nodules on a neck exam. We can't just look at lab values and make a diagnosis.
Avatar universal
Thanks for the reply and information. It really helped a lot.

Yes. I will continue on the 50mg and get my lab work done on sep 17th.
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Avatar universal
When taking thyroid med, the TSH test is basically useless.  The most important consideration is symptoms, followed by Free T4 and Free T3 levels. Your Free T4 and Free T3 levels are lower than optimal for many people, and your TPO ab was reported high, but you have no symptoms other than irregular periods.  It could be that you are in the early stages of Hashimoto's Thyroiditis, so I think I would continue on the 50 mcg of T4 med and do some followup testing in about 6-8 weeks.  This proactive approach will help prevent you from having bad symptoms farther along.  

It is somewhat unusual for a provider to go ahead and prescribe meds as done here.  I see it as a good thing since more normally the patient has to scratch and claw to get thyroid meds, until test results are extreme.  
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Avatar universal
I never had any hypo thyroid symptom other than irregular periods from couple of months.
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Avatar universal
Thanks for the reply Gimel.

Because after using 75mg, my TSH was 0.01 which is very low and fT4 was high. So, I waited for 1 month without any medication and went for lab test again. Then I got my thyroid levels as mentioned above. So, now, my doctor prescribed me 50mg.
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Avatar universal
Why did your provider ask you to reduce your dosage from 75 to 50 mcg?   What symptoms do you have?

You don't really take meds for TG ab.  Either TG antibodies or TPO antibodies diminish the ability of the thyroid gland to produce hormone.  So, you take thyroid meds to supplement the reduced amount of thyroid hormone produced by the thyroid gland.  

A good thyroid doctor will treat a hypo patient clinically by testing and adjusting Free T4 and free t3 as necessary to relieve hypothyroid symptoms, without being constrained by resultant TSH levels.  Symptom relief should be all important to you, not just test results and especially not TSH results when already taking thyroid meds.  You can get some good info from this link written by a good thyroid doctor.  

http://www.hormonerestoration.com/Thyroid.html

If you still have hypo symptoms then you need to increase your meds, not decrease.  Many members here say that relief from hypo symptoms required Free T4 at the middle of its range, at minimum, and Free T3 in the upper third of its range, or as needed to relieve symptoms.  

Since hypothyroid patients are frequently too low in the ranges for Vitamin D, B12 and ferritin, those should be tested and supplemented as needed to optimize.  D should be about 55-60, B12 in the very upper end of its range, and ferritin should be about 70 minimum.
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